Alprostadil cream and injections

In the realm of erectile dysfunction (ED) treatment, Alprostadil has emerged as a highly effective solution that brings hope to millions of men worldwide. With its unique mechanism of action, Alprostadil offers a reliable option for those seeking to regain their sexual confidence. In this article, we will delve into the intricacies of Alprostadil cream and injections, exploring their role in combating ED. We will examine whether Alprostadil is a first-choice treatment for this condition and shed light on the circumstances under which healthcare professionals may prescribe it. 

How is Alprostadil used to treat erectile dysfunction?

Alprostadil is used to treat erectile dysfunction (ED) by improving blood flow to the penis, thereby helping the user to get an erection. It is available in two main forms: cream and injections. Alprostadil cream, also known as topical Alprostadil, is applied directly to the tip of the penis. The cream is absorbed through the skin and works by dilating the blood vessels, increasing blood flow, and promoting an erection. Alprostadil injections involve the direct injection of the medication into the base or side of the penis using a fine needle. This method also enhances blood flow, leading to a firm and lasting erection.

Is Alprostadil a first-choice treatment for ED?

Alprostadil is not typically considered a first-choice treatment for erectile dysfunction (ED). It is usually reserved for cases where other treatment options, such as oral medications like sildenafil (Viagra) or tadalafil (Cialis), have not been effective. Alprostadil may be recommended as a second-line or alternative treatment for individuals who are unable to take or have not responded well to oral medications. However, the specific treatment approach for ED can vary depending on the underlying cause, individual preferences, and medical considerations.

What circumstances would Alprostadil be prescribed under?

Some circumstances in which Alprostadil may be prescribed include:

• Failure of oral medications:  If oral medications like sildenafil or tadalafil have not provided satisfactory results or cannot be used due to medical conditions, Alprostadil may be considered as an alternative.

• Some neurological conditions: Alprostadil injections may be prescribed for individuals with neurological conditions that affect their ability to achieve or maintain an erection, such as spinal cord injury or multiple sclerosis.

• Patient preference: Alprostadil may be chosen as a treatment option based on individual preferences, such as convenience or personal comfort with the method of administration.

What is Prostaglandin E1 (PGE1)?

Prostaglandin E1 (PGE1) is a naturally occurring hormone-like substance that plays a crucial role in various physiological processes within the body. It belongs to the prostaglandin family, which consists of lipid compounds with hormone-like effects.  PGE1 is derived from arachidonic acid and is involved in regulating inflammation, blood flow, and smooth muscle function.

Is Alprostadil a PGE1?

Yes, Alprostadil is a synthetic form of prostaglandin E1 (PGE1). It is designed to mimic the effects of naturally occurring PGE1 in the body. By acting as a vasodilator and promoting smooth muscle relaxation, Alprostadil improves blood flow to the penis, facilitating the ability to achieve and maintain an erection. 

What are the differences between a PGE1 and PDE5-inhibitor?

PGE1 and PDE5 inhibitors (phosphodiesterase type 5 inhibitors) are two different classes of medications used in the treatment of erectile dysfunction (ED). They have different mechanisms of action. PGE1 works by directly promoting vasodilation and smooth muscle relaxation. PDE5 inhibitors work by inhibiting the enzyme phosphodiesterase type 5. Here is a handy table for the main differences between the two.

What are the common side effects of Alprostadil?

As with other prescription-only medications, there are a number of side effects that alprostadil users may experience when they use the medication. The most common of which include:

• Penile pain or discomfort

• Urethral burning or irritation

• Priapism, a condition that causes prolonged, painful erections

• Redness or swelling

• Hypotension, a drop in blood pressure

What are the uncommon side effects of Alprostadil?

There are some other, more uncommon side effects of alprostadil, including:

• Fibrosis, which can cause penile curvature or deformity

• Allergic reactions

• Hypersensitivity causing effects such as redness, swelling or itching

• Urinary tract conditions

Is Alprostadil a vasodilator?

Yes, Alprostadil is a vasodilator. It works by directly promoting the dilation or widening of blood vessels, including those in the penis. As a vasodilator, Alprostadil helps to improve blood flow to the erectile tissues of the penis, facilitating the ability to achieve and maintain an erection. By dilating the blood vessels, Alprostadil enhances the delivery of oxygen and nutrients to the penile tissues, leading to a firm and sustained erection. 

How fast will Alprostadil produce an erection?

The speed at which Alprostadil produces an erection can vary depending on the individual and the method of administration (cream or injection). Alprostadil cream usually takes effect within 5 to 30 minutes. The injectable version of the medication provides results within 5 to 20 minutes.

How long does Alprostadil last?

The duration of action of Alprostadil can vary depending on the individual, the dose administered, and the method of administration. Both alprostadil cream and alprostadil injections will last for around 1 to 2 hours.

Does the form of Alprostadil being used affect how long it will last?

No, both alprostadil cream and alprostadil injections will last for around 1 to 2 hours. It's crucial to follow the instructions provided by the healthcare professional and not exceed the recommended dosage or frequency of administration. If you have a prolonged erection for over 4 hours you may wish to seek medical attention as this can be an emergency. 

How long does Alprostadil cream last?

Alprostadil cream typically lasts for about 1 to 2 hours. After applying Alprostadil cream to the tip of the penis, it is absorbed through the skin and begins to take effect within approximately 5 to 30 minutes. During this time, the penis may remain in a partially erect or engorged state. However, the duration of the effect can vary between individuals. 

How do you use Alprostadil cream?

Alprostadil cream is straight forward to use to achieve the results you want. You can find instructions on the patient information leaflet included with your medication, or you can follow the following instructions:

• Wash your hands thoroughly with warm water and soap

• Apply the cream to the tip of your penis

• Massage the cream into the head and shaft of the penis

• Wait around 5 to 30 minutes before engaging in sexual activity

How do you use an Alprostadil injection?

It is important that you use alprostadil injections correctly. You should ALWAYS follow the instructions provided with the medication before using. When using injection equipment you should ensure that you are remaining safe and not doing things such as sharing needles. 

What forms can Alprostadil come in?

Alprostadil can come in a number of different forms. The most common form of alprostadil is cream or injections, however, people often go for the cream over the injection. There is also another form of alprostadil that people can use, a urethral suppository that is inserted into the urethra using a special applicator. 

What brand names does Alprostadil have?

Alprostadil and the different forms of alprostadil that you can get can come in different names. The most common form of alprostadil is cream and the most common brand name for this is Vitaros. 

Who is Alprostadil not suitable for?

Alprostadil may not be suitable for everyone. It is important to consult with a healthcare professional who can evaluate your medical history, overall health, and any specific contraindications or precautions. Generally, Alprostadil may not be suitable for individuals who:

• Are allergic or hypersensitive to alprostadil

• Have a history of certain medical conditions such as priapism

• Have conditions that increase the risk of bleeding

• Have a genital infection or inflammation

• Have been advised against sexual activity

Do I need a prescription to buy Alprostadil?

Yes, in order to purchase and use alprostadil cream or injections you will need to have a prescription. 

Can I get a prescription for Alprostadil online?

Yes, you can get a prescription for alprostadil online to save you a visit to the GP or pharmacy to discuss a potentially embarrassing condition.

Where can I buy Alprostadil online?

You can purchase alprostadil cream, particularly Vitaros, online from UK Meds. Simply complete our FREE online consultation that ensures that the medication is right for you.

Sources

• Patient.info - Alprostadil for Erectile Dysfunction

• Newcastle Hospitals NHS - Penile Injections for Erectile Dysfunction (Impotence)

• Cambridge University Hospitals NHS - Penile Injections for Impotence

• Prostate Cancer UK Community - Alprostadil Injections and Cream

• Drug and Therapeutics Bulletin - Alprostadil Injections for Erectile Dysfunction

• NICE CKS - Erectile Dysfunction

• NHS - Erection Problems (Erectile Dysfunction)

• BNF - Alprostadil

• NICE - Alprostadil Cream for Erectile Dysfunction (PDF)

• Medicines.org.uk - Alprostadil Summary of Product Characteristics

• Dovepress - Clinical Use of Alprostadil Topical Cream in Patients with Erectile Dysfunction

• East and North Hertfordshire CCG - Alprostadil Cream (Vitaros) for Erectile Dysfunction (PDF)